Lipid Alterations in Renal Membrane of Stroke‐Prone Spontaneously Hypertensive Rats
作者:
Hiroshi Okamoto,
Hideaki Kawaguchi,
Masaru Minami,
Hideya Saito,
Hisakazu Yasuda,
期刊:
Hypertension
(OVID Available online 1989)
卷期:
Volume 13,
issue 5
页码: 456-462
ISSN:0194-911X
年代: 1989
出版商: OVID
关键词: phosphohpase A2;phospholipid;renal membrane;fatty acids;stroke-prone spontaneously hypertensive rats
数据来源: OVID
摘要:
Phospholipase A2activity, pbospholipids, and phospholipid fatty acids were investigated in renal membrane of male stroke-prone spontaneously hypertensive rats (SHRSP) and age-matched Wistar-Kyoto rats. Renal phospholipase A2activity increased and membranous phospholipids, especially phosphatidylchoUne and phosphatidylethanolamine, decreased with age in SHRSP. Arachidonate in phospholipid also decreased with age in SHRSP. To determine the effect of pressure load on the lipid alterations in renal membrane, SHRSP that received antihypertensive treatment with hydralazine, enalapril, or nicardipine for 5 weeks were compared with those without treatment. Antihypertensive treatments prevented phospholipid degradation and increased arachidonate in phospholipid relative to the control group. Phospholipase A2 activity in each group treated with antihypertensive drugs did not differ from that in the control group. These results suggest that the course of hypertension causes renal membranous phospholipid degradation and increases phospholipase A2activity. Antihypertensive treatments may prevent these lipid alterations in SHRSP. These renal membranous structural changes may provide an explanation not only for functional abnormalities such as decreased membrane fluidity but also for the progress of hypertension.
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