The Pharmacokinetics of Sufentanil in Surgical Patients
作者:
James Bovill,
Peter Sebel,
Cordelia Blackburn,
Vivian Oei-Lim,
Jos Heykants,
期刊:
Anesthesiology
(OVID Available online 1984)
卷期:
Volume 61,
issue 5
页码: 502-506
ISSN:0003-3022
年代: 1984
出版商: OVID
关键词: Analgesics:;sufentanil.;Anesthetics,;intravenous:;sufentanil.;Pharmacokinetics:;sufentanil.;Surgery.
数据来源: OVID
摘要:
The pharmacokinetics of sufentanil, a new thienyl analogue of fentanyl, were studied in 10 surgical patients. Sufentanil, 5 μg/kg, was given intravenously as a bolus injection and plasma concentrations measured at intervals up to 8 h. Plasma sufentanil concentrations decreased rapidly after injection—98% of the administered dose having left the plasma within 30 min. In 9 of the 10 patients, a tri-exponential equation optimally described the sufentanil concentration decay curve, with average (±SEM) half-lives for the rapid (π) and slow (α) distribution phases of 1.4 ± 0.3 min and 17.7 ± 2.6 min, respectively. The average terminal elimination (β) half-life was 164 ± 22 min. The average value for Vdβ was 2.9 ± 0.2 1/kg, Vdss1.7 ± 0.2 1/kg and total plasma clearance 12.7 ± 0.8 ml · kg-1· min-1(935 ± 50 ml/min). In one patient, a biexponential equation was sufficient to describe the concentration-time data, yielding a distribution half-life of 4.7 min and an elimination half-life of 117 min.
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