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Conventional vs. Newer Antipsychotics in Elderly Patients

 

作者: Dilip Jeste,   Enid Rockwell,   M. Harris,   James Lohr,   Jonathan Lacro,  

 

期刊: American Journal of Geriatric Psychiatry  (OVID Available online 1999)
卷期: Volume 7, issue 1  

页码: 70-76

 

ISSN:1064-7481

 

年代: 1999

 

出版商: OVID

 

关键词: Antipsychotics;Pharmacotherapy;New Drugs

 

数据来源: OVID

 

摘要:

Elderly patients with schizophrenia and dementia patients with agitation are frequently candidates for antipsychotic treatment. Conventional neuroleptics have relatively little effect on negative symptoms and may cause considerable side effects, especially in elderly patients. The authors have found a 29% cumulative annual incidence of tardive dyskinesia (TD) in middle-aged and elderly outpatients treated with relatively low doses of conventional neuroleptics. Newer antipsychotics are less likely to cause extrapyramidal symptoms and may be associated with a lower risk of TD. They are generally effective for both positive and negative symptoms and may also improve some aspects of cognition, but these drugs have their own side effects. Dosing requirements for elderly patients tend to be much lower than those for younger adults.

 

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