Kv1.1 channel antisense attenuates learning and modulation of dentate polysialylated NCAM
作者:
Elena Gratacós,
Carla Ghelardini,
Lisa Gherardini,
Nicoletta Galeotti,
Keith Murphy,
Alessandro Bartolini,
Ciaran Regan,
期刊:
NeuroReport
(OVID Available online 1998)
卷期:
Volume 9,
issue 12
页码: 2727-2731
ISSN:0959-4965
年代: 1998
出版商: OVID
关键词: Granule cells;Hippocampal formation;Neuroplasticity;Passive avoidance;Voltage-gated potassium channels
数据来源: OVID
摘要:
THE distribution and modulation of neural cell adhesion molecule polysialylation state (NCAM PSA) and the consequence of antisense inactivation of the Kv1.1 potassium channel was investigated following avoidance learning in mice. PSA immunoreactivity was most notable on cells at the inner denate border and in cortical layer II. Task acquisition resulted in a significant 30% transient increase in the frequency of dentate polysialylated neurons at the 1 2 h post-training time. In contrast, animals pretreated with the Kv1.1 antisense oligonucleotide exhibited both attenuated recall avoidance latencies and polysialylated cell frequency. As Kv1.1 is enriched on the dendrites of these granule-like cells, the attenuated polysialylation response is considered secondary to NCAM-mediated events during their transient synapse production in the 6–8 h post-training period.
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