Increased survival of dopaminergic neurons by rasagiline, a monoamine oxidase B inhibitor
作者:
John M. Finberg,
Takao Takeshima,
Jane Johnston,
John Commissiong,
期刊:
NeuroReport
(OVID Available online 1998)
卷期:
Volume 9,
issue 4
页码: 703-707
ISSN:0959-4965
年代: 1998
出版商: OVID
关键词: Dopaminergic neurons;GABAergic neurons;Microisland cultures;Neurodegenerative diseases;Neuronal survival;Parkinson's disease;Tissue culture
数据来源: OVID
摘要:
BOTH deprenyl and rasagiline (R(+)-N-propargyl-1–aminoindane mesylate), at a concentration of 1–1 μM, increased survivalin vitroof rat E14 mesencephalic dopaminergic neurons that had been primed with 10% serum for 1 2 h (p< 0.05). Rasagiline, but not deprenyl, also increased total neuronal (MAP2–positive) survival (p< 0.05) Under serum-free conditions, rasagiline, but not deprenyl, retained its neuroprotective action on dopaminergic neurones. GABAergic neurons were not affected by either deprenyl or rasagiline. Clorgyline, an MAO-A inhibitor, did not exert any of these effects. The protective action of rasagiline on dopaminergic neurons, even under stringent serum-free conditions, is striking, and warrants further investigation for a role in the treatment of Parkinson's disease.
点击下载:
PDF
(1021KB)
返 回