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Reproducibility of the French‐American‐British classification of acute Leukemia: The southwest oncology group experience

 

作者: David R. Head,   Richard A. Savage,   Lizardo Cerezo,   Catherine M. Craven,   John N. Bickers,   Robert Hartsock,   Thomas A. Hosty,   John H. Saiki,   Henry E. Wilson,   Francis S. Morrison,   Charles A. Coltman,   John J. Hutton,  

 

期刊: American Journal of Hematology  （WILEY Available online 1985）
卷期: Volume 18, issue 1  

页码: 47-57

 

ISSN:0361-8609

 

年代: 1985

 

DOI:10.1002/ajh.2830180108

 

出版商: Wiley Subscription Services, Inc., A Wiley Company

 

关键词: acute leukemia;FAB

 

数据来源: WILEY

 

摘要:

AbstractAfter initial French‐American‐British (FAB) diagnosis by a multiinstitutional Southwest Oncology Group panel, slides of acute leukemia cases were recirculated to panel members for second review. The reproducibility of the FAB classification is analyzed. The classification is reproducible in the 70% range in panel reviewer hands and allows remarkable reproducibility in the morphologic and cytochemical distinction of acute lymphoid leukemia (ALL) from acute myeloid leukemia (AML). The limitations of a morphologic and cytochemical classification of acute leukemia are discussed. A simplification of the FAB system, merging M1, M2, and M4 as M7, is proposed; this simplification improves the system's reproducibil

 

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