D‐Cycloserine, a partial NMDA recepto r‐associated glycine‐B site agonist, enhances reversal learning, but a cholinesterase inhibitor and nicotine has no effect
作者:
Paavo Riekkinen,
Sami Ikonen,
Minna Riekkinen,
期刊:
NeuroReport
(OVID Available online 1998)
卷期:
Volume 9,
issue 16
页码: 3647-3651
ISSN:0959-4965
年代: 1998
出版商: OVID
关键词: Alzheimer's disease;D-cycloserine;Combined therapy;Nicotine;Reversal learning in water maze;THA
数据来源: OVID
摘要:
THE present study examined the efficacy of single and combined treatments with an anticholinesterase, tetrahydroaminoacridine, nicotine and a glycine-B site partial agonist, D-cycloserine, in alleviating the water maze reversal learning defect induced by a medial septal lesion. D-cycloserine (3 and 10 mg/kg) improved reversal learning. Tetrahydroaminoacridine (1 and 3mg/kg) and nicotine (0.1 and 0.3 mg/kg) had no effect on reversal learning. A combination of tetrahydroaminoacridine 3 mg/kg or nicotine 0.3 mg/kg and D-cycloserine 10 mg/kg was not more effective than D-cycloserine 10 mg/kg alone in improving reversal learning. This suggests that stimulation of NMDA mechanisms may more effectively improve in medial septal-lesioned rats reversal learning processes than stimulation of cholinergic activity.
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