Chemoradiotherapy of Anal Carcinoma: Tumour Response and Acute Toxicity
作者:
Gunnar Tanum,
Kjell M. Tveit,
Karl O. Karlsen,
期刊:
Oncology
(Karger Available online 1993)
卷期:
Volume 50,
issue 1
页码: 14-17
ISSN:0030-2414
年代: 1993
DOI:10.1159/000227140
出版商: S. Karger AG
关键词: Anal carcinoma;Radiotherapy;Chemotherapy;Response;Toxicity
数据来源: Karger
摘要:
This study was performed to evaluate local tumour control and toxicity of chemoradiotherapy given to patients with primary or recurrent carcinoma of the anal canal. A total of 117 patients were admitted to the Norwegian Radium Hospital during the period of 1983-1989, of which 106 received a combination of radiotherapy (50 Gy to the pelvis) and chemotherapy (mitomycin C + 5-fluorouracil). Sixty-five percent of the patients with primary carcinomas presented with advanced tumours (T3 or T4). Good local tumour control was obtained as only 25% of the patients with advanced tumours (T3 and T4) and 7% of those with smaller tumours (T1, and T2) had a local relapse after treatment. Recurrent tumours following primary surgery did not respond as well; 50% of these patients still had carcinoma 1 month following therapy. All patients experienced acute toxicity (dermatitis/mucositis, diarrhoea and general fatigue), and 50% needed as split course. There was, however, no therapy-related mortality. Survival data seem promising, but further follow-up is necessary to make conclusions. Eight percent of the patients had serious anal insufficiency after treatment. We conclude that the present regimen provides good local tumour control and well-preserved anal function, but has considerable acute toxicity.
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