The transformation of traditional agriculture to agricultural systems which foster growth and development requires the availability of improved crop production and crop protection inputs, as well as the skills to safely and effectively utilize these inputs. The typical progression of agricultural development involves an initial focus on increasing crop yields, with pest management as a secondary consideration and the safety and health aspects of agricultural practices as tertiary considerations. This common hierarchy can lead to inefficiencies because of the close interrelatedness of crop production and crop protection in determining the profitability and stability of new agricultural systems. This article outlines the advantages of simultaneous rather than sequential address of crop production, protection, and safety in agricultural development.