It was our Intention to verify If Increases of granulocyte colony stimulating factor (G-CSF) dose were able to reduce treatment delays due to leukopenia in our weekly regimen of clsplatin (40 mg/m2), epidoxorublcin (35 mg/m2), SS-leucovorin (250 mg/m2 and 5-fluorouracil (500 mg/m2), usually supported by G-CSF at a dose of 5 μg/kg. Forty five patients with advanced gastric carcinoma (30 males and 15 famales; median age 64 years) were randomized to receive three different doses of G-CSF (5, 8 and 10 μ/kg) by s.c. Injection. We did not observe any difference in the mean value of neutrophil counts at each of the 8 weeks of treatment; while we registered a higher incidence of severe neutropenia (3) in pattents receiving higher G-CSF doses: two patients in the group at 5 μg/kg, four in the group at 8 μg/kg and seven in the group at 10 μg/kg. Furthermore, low doses of G-CSF allowed a similar number of chemotherapeutic administrations in the eight study weeks. The results arising from our study do not seem to support the use of higher doses of G-CSF, at least in not such a weekly regimen.