Pharmacokinetics of Zidovudine (Azidothymidine). II. Development of Metabolic and Renal Clearance Pathways in the Neonate
作者:
Arturo Lopez-Anaya,
Jashvant Unadkat,
Louise Schumann,
Arnold Smith,
期刊:
Journal of Acquired Immune Deficiency Syndromes
(OVID Available online 1990)
卷期:
Volume 3,
issue 11
页码: 1052-1058
ISSN:0894-9255
年代: 1990
出版商: OVID
关键词: Zidovudine;azidothymidine;Pharmacokinetics;Neonates;Macaques;Macaca nemestrina;UDP glucuronosyltransferase;Zidovudine glucuronide;AIDS;HIV infection.
数据来源: OVID
摘要:
SummaryThe pharmacokinetics of zidovudine (ZDV or azidothymidine) were investigated in newborn macaques (Macaca nemestrina) at various ages ranging from less than 1 week to 4 months. The mean ZDV total plasma clearance, renal clearance, and the metabolic clearance of ZDV to the glucuronide (ZDVG) were significantly (p < 0.05) smaller during the first week of life (6.15 ± 1.03, 4.25 ± 0.36, and 1.19 ± 0.67 ml/min/kg, respectively) than the corresponding estimates at the age of 4 months (19.62 ± 3.5, 8.28 ± 1.90, and 8.28 ± 2.24 ml/min/kg, respectively). The mean estimates of these parameters at 4 months were close to those found in adult macaques (23.55 ± 1.48, 10.05 ± 0.75, and 10.5 ± 1.9 ml/min/kg, respectively), indicating that these clearance pathways develop rapidly, within 4 months of birth. If similar results are obtained in human neonates, therapeutic drug monitoring should be instituted when administering ZDV to this population so that the dose of ZDV may be adjusted to correspond with age-related changes in total plasma clearance of ZDV.
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