Age-Related Changes in Central Nervous System Beta-Endorphin and ACTH
作者:
S.R. Gambert,
T.L. Garthwaite,
C.H. Pontzer,
T.C. Hagen,
期刊:
Neuroendocrinology
(Karger Available online 1980)
卷期:
Volume 31,
issue 4
页码: 252-255
ISSN:0028-3835
年代: 1980
DOI:10.1159/000123083
出版商: S. Karger AG
关键词: β-Endorphin;Age;ACTH;Pituitary;Brain
数据来源: Karger
摘要:
Aging is associated with alterations in mood, thermoregulation, pain threshold, and stress response. Because these functions may be modulated by endogenous opiates, we measured immunoreactive ACTH and β-endorphin in discrete brain areas and pituitary glands from rats aged 6 weeks (young), 6 months (mature), and 20–24 months (senescent). β-Endorphin and ACTH declined significantly with aging in the hypothalamus and corpus striatum. β-Endorphin and ACTH increased in the frontal lobe during early life; however, no change was noted after maturity. A discordant response with age was noted in the pituitary in that ACTH did not change, while β-endorphin increased early in life without change after maturity. Cerebellar tissue exhibited no immunoreactive ACTH or β-endorphin. Age-related changes in brain and pituitary β-endorphin and ACTH must be considered in the evaluation of the physiological aging process and when comparing studies of these neurop
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