Hydrogen bond association constants of some nucleoside base pairs formed by an adenosine derivative and anticancer agents
作者:
R. Buchet,
C. Sandorfy,
期刊:
International Reviews in Physical Chemistry
(Taylor Available online 1986)
卷期:
Volume 5,
issue 2-3
页码: 153-160
ISSN:0144-235X
年代: 1986
DOI:10.1080/01442358609353377
出版商: Taylor & Francis Group
数据来源: Taylor
摘要:
Base-pair and trimer formation between certain adenosine derivatives and anticancer agents has been studied by Fourier-transform infrared spectroscopy by determining hydrogen-bond association constants. The results indicate that the anticancer agents studied have a preference for Hoogsteen over Watson-Crick type base-pair formation and that they have an appreciable tendency for trimer formation. This might be the way in which they interfere with site recognition and hinder unwarranted protein formation.
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