Functional Differences of T cells in B-Chronic Lymphocytic Leukemia
作者:
AnticaMariastefania,
KušićBorka,
SpaventiRadan,
JaksićBranimir,
VitaleBranko,
期刊:
Leukemia&Lymphoma
(Taylor Available online 1993)
卷期:
Volume 9,
issue 1-2
页码: 133-140
ISSN:1042-8194
年代: 1993
DOI:10.3109/10428199309148516
出版商: Taylor&Francis
关键词: T cells in B-CLL;lymphocytic leukemia
数据来源: Taylor
摘要:
B cell chronic lymphocytic leukemia (B-CLL) is a disease characterized by an accumulation of monoclonal lymphocytes of B cell origin. Although the neoplastic process involves the B lymphocyte compartment, phenotypic and functional defects within the T lymphocyte population implicate their possible role in the pathogenesis of the disease. We analyzed the functional and morphological integrity of T lymphocytes from the peripheral blood of 64 patients with B-CLL. The activation of B-CLL T cells after PHA stimulation was determined by measuring [3H]-thymidine incorporation, assessing cell numbers in parallel cultures, and by monitoring the lymphocyte subsets during 9 days of cultivation. Our results indicate the presence of three functionally different populations of T cells in the peripheral blood of B-CLL patients. We present evidence for an increased proliferative potential of T lymphocytes from a group of patients with B-CLL.
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