Long-Term Efficacy and Safety of Somatropin for Adult Growth Hormone Deficiency
作者:
Johan Svensson,
Gudmundur Johannson,
期刊:
Treatments in Endocrinology
(ADIS Available online 2003)
卷期:
Volume 2,
issue 2
页码: 109-120
ISSN:1175-6349
年代: 2003
出版商: ADIS
关键词: Somatropin, therapeutic use;Somatotropin deficiency, treatment;Growth hormone agonists, therapeutic use
数据来源: ADIS
摘要:
The beneficial effects of somatropin (growth hormone [GH] replacement therapy) in adults are now established. Long-term somatropin administration in GH-deficient adults improves body composition, muscle strength, quality of life, bone mass and density, and lipoprotein pattern. The extent to which somatropin therapy can also reduce cardiovascular morbidity and mortality in GH-deficient adults remains to be determined.By starting with a low dose of somatropin, which is gradually increased based on clinical response (body composition, well-being, and serum insulin-like growth factor-1 concentration), effective treatment can be achieved with a minimum of fluid-related adverse effects. Thorough long-term monitoring of glucose metabolism, cardiovascular measurements, and underlying pituitary disease, is, however, mandatory.
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