Short Courses of Antibiotics in Selected Febrile Neutropenic Patients
作者:
ANDREW KAPLAN,
DAVID WEBER,
LORI DAVIS,
FRANKLIN ISRAEL,
ROBERT WELLS,
期刊:
The American Journal of the Medical Sciences
(OVID Available online 1991)
卷期:
Volume 302,
issue 6
页码: 353-354
ISSN:0002-9629
年代: 1991
出版商: OVID
关键词: Antibiotics;short courses;Febrile neutropenic patient
数据来源: OVID
摘要:
To evaluate their policy of discontinuing broad spectrum antibiotics in patients with negative cultures who become afebrile but remain neutropenic, the authors retrospectively reviewed the charts of all pediatric patients diagnosed with cancer between 1980 and 1986. Two hundred seventy-one children had 385 admissions for infectious complications during the study period. In 39 of those episodes (9%), the patients had negative cultures, became afebrile, and were discharged with absolute neutrophil counts of<1000 cells/mm3 (mean 390 cells/ mm3). They received relatively short courses of antibiotics with a median duration of 4 days. Only four of these patients became febrile during the followup period and there were no fatalities. Given the benign course of these patients, recommendations for prolonged antibiotic courses should be reconsidered.
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