Estradiol upregulates Bcl‐2 expression in adult brain neurons
作者:
Luis Garcia-Segura,
Patricia Cardona-Gomez,
Frederick Naftolin,
Julie Chowen,
期刊:
NeuroReport
(OVID Available online 1998)
卷期:
Volume 9,
issue 4
页码: 593-597
ISSN:0959-4965
年代: 1998
出版商: OVID
关键词: Apoptosis;Estrogen;Estrous cycle;Hypothalamus;Neural plasticity;Neuronal death;Progesterone
数据来源: OVID
摘要:
BCL-2, a protein which negatively modulates apoptosis, is up-regulated by estrogen in several tissues. To determine the effect of estradiol on Bcl-2 in the adult brain, its immunoreactive distribution was examined in the hypothalamic arcuate nucleus of female rats under different endocrine conditions. The number of Bcl-2–immunoreactive neurons was significantly increased (p< 0.001) on the day of estrus compared with proestrus, diestrus and metestrus, was decreased by ovariectomy and showed a dose–response increase after estradiol administration to ovariectomized rats. Progesterone, when injected simultaneously with estradiol, reduced the effect of estradiol. These findings indicate that ovarian hormones regulate Bcl-2 in hypothalamic neurons and suggest that this protein may be involved in the neuro-protective effects of estrogen.
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