Effect of Transforming Growth Factor-Beta 1 and -Beta 2 on the Proliferation of Burkitt Lymphoma and Lymphoblastoid Cell Lines
作者:
AltiokAysin,
BejaranoMaria Teresa,
RuscettiFrank,
AltiokEnder,
KleinGeorge,
KleinEva,
期刊:
Growth Factors
(Taylor Available online 1991)
卷期:
Volume 4,
issue 2
页码: 117-128
ISSN:0897-7194
年代: 1991
DOI:10.3109/08977199109000263
出版商: Taylor&Francis
关键词: Transforming growth factor beta;lymphoblastoid cell line;Burkitt lymphoma;Epstein-Barr virus;growth inhibition;TGF-beta receptor
数据来源: Taylor
摘要:
AbstractWe tested the effect of transforming growth factor (TGF)-beta 1 and TGF-beta 2 on the proliferation of human B cell lines. The panel was selected to give information whether (1) their origin, (2) their phenotype, (3) their Epstein-Barr virus (EBV) carrier state, influence their responsiveness. The growth of lymphoblastoid cell lines (LCL) was not inhibited by TGF-beta 1. The EBV-carrying Burkitt lymphoma (BL) lines, Daudi, Jijoye, Rael but not Raji were inhibited. Three EBV-negative BL lines and the majority of their converted sublines were sensitive. The cell lines tested expressed TGF-beta receptors and TGF-beta 1 transcripts. The proliferation of EBV-infected B cells was inhibited by TGF-beta, their sensitivity decreased, however, after 3 days. The results suggest that the activation state of the B cells is decisive for TGF-beta sensitivity and EBV influences it indirectly by changing the cell phenotype
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