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Effect of Transforming Growth Factor-Beta 1 and -Beta 2 on the Proliferation of Burkitt Lymphoma and Lymphoblastoid Cell Lines

 

作者: AltiokAysin,   BejaranoMaria Teresa,   RuscettiFrank,   AltiokEnder,   KleinGeorge,   KleinEva,  

 

期刊: Growth Factors  (Taylor Available online 1991)
卷期: Volume 4, issue 2  

页码: 117-128

 

ISSN:0897-7194

 

年代: 1991

 

DOI:10.3109/08977199109000263

 

出版商: Taylor&Francis

 

关键词: Transforming growth factor beta;lymphoblastoid cell line;Burkitt lymphoma;Epstein-Barr virus;growth inhibition;TGF-beta receptor

 

数据来源: Taylor

 

摘要:

AbstractWe tested the effect of transforming growth factor (TGF)-beta 1 and TGF-beta 2 on the proliferation of human B cell lines. The panel was selected to give information whether (1) their origin, (2) their phenotype, (3) their Epstein-Barr virus (EBV) carrier state, influence their responsiveness. The growth of lymphoblastoid cell lines (LCL) was not inhibited by TGF-beta 1. The EBV-carrying Burkitt lymphoma (BL) lines, Daudi, Jijoye, Rael but not Raji were inhibited. Three EBV-negative BL lines and the majority of their converted sublines were sensitive. The cell lines tested expressed TGF-beta receptors and TGF-beta 1 transcripts. The proliferation of EBV-infected B cells was inhibited by TGF-beta, their sensitivity decreased, however, after 3 days. The results suggest that the activation state of the B cells is decisive for TGF-beta sensitivity and EBV influences it indirectly by changing the cell phenotype

 

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