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Synthesis, mechanism of action, and QSAR of herbicidal 3‐substituted‐2‐aryl‐4,5,6,7‐tetrahydroindazoles

 

作者: John W. Lyga,   Russell M. Patera,   Marjorie J. Plummer,   Blaik P. Halling,   Debra A. Yuhas,  

 

期刊: Pesticide Science  （WILEY Available online 1994）
卷期: Volume 42, issue 1  

页码: 29-36

 

ISSN:0031-613X

 

年代: 1994

 

DOI:10.1002/ps.2780420106

 

出版商: John Wiley&Sons, Ltd

 

数据来源: WILEY

 

摘要:

AbstractA factorially designed set of 3‐substituted 2‐aryl‐4,5,6,7‐tetrahydroindazoles was synthesized and their herbicidal properties were evaluated using regression analysis. For optimal activity, the substituent at position 3 should be neither strongly hydrophobic nor hydrophilic and should have a small minimum radius. A study of the mechanism of action indicated that the tetrahydroindazoles are inhibitors of the enzyme protoporphyrinogen

 

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