Protracted Infusion of 5-FU with Weekly Low-Dose Cisplatin as Second-Line Therapy in Patients with Metastatic Colorectal Cancer Who Have Failed 5-FU Monotherapy
作者:
AhlgrenJames D.,
TrockiOrrawin,
GulloJohn J.,
GoldbergRichard,
MuirW. Angus,
SiskRegina,
SchacterLee,
期刊:
Cancer Investigation
(Taylor Available online 1991)
卷期:
Volume 9,
issue 1
页码: 27-33
ISSN:0735-7907
年代: 1991
DOI:10.3109/07357909109032797
出版商: Taylor&Francis
数据来源: Taylor
摘要:
AbstractForty four patients who had documented progression of mestastatic colorectal cancer while receiving 5-fluorouracil (5-FU) monotherapy were treated with continuous infusion 5-FU, 300 mg/mg2/day, plus weekly low-dose cisplatin, 20 mg/m2. Treatment was given in 12-week cycles, consisting of 8 weeks of chemotherapy followed by a 4-week rest period, and was well tolerated. Three of 23 patients (13%) who had failed bolus 5-FU but not been exposed previously to infusional 5-FU responded. Of 21 patients who had failed infusional 55-FU monotherapy, only one (5%) responded. Time to progression (5.7 vs. 1.8 months) and survival (12 vs. 5.5 months) were significantly longer for patients who had not previously received infusional 5-FU but who had failed bolus schedules, compared with patients who had previously failed infusional 5-FU (p<.001).
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