A‐68930, a novel potent dopamine D1 receptor agonista microstructural analysis of its effects on feeding and other behaviour in the rat
作者:
H. Al-Naser,
S. Cooper,
期刊:
Behavioural Pharmacology
(OVID Available online 1994)
卷期:
Volume 5,
issue 2
页码: 210-218
ISSN:0955-8810
年代: 1994
出版商: OVID
关键词: A-68930;Dopamine D1 receptor;Feeding;Grooming;Locomotion;Rat;Rearing
数据来源: OVID
摘要:
A-68930 [1R,3S)-1-aminomethyl-5,6-dihydroxy-3-phenylisochroman HCI] is a novel, potent and selective dopamine D1 receptor agonist. Previous reports have shown that the selective D1 partial agonist, SK&F 38393, reduced food consumption in rats and mice. The aim of this study was to undertake a microstructural analysis of the effects of A-68930 on food intake and feeding behaviour in non-deprived male rats trained to consume a highly palatable diet in a 20 min period. A-68930 (0.1–1.0 mg/kg, s.c.) produced a dose-dependent reduction in food intake, which was due to a reduction in the frequency of bouts of feeding but not to a reduction in bout duration. A-68930 had little effect on the latency to initiate feeding or on the local rate of eating. Hence, it had a selective action on the parameters of eating, which is distinctly different from the effects of selective D2 agonists or of indirectly acting psychomotor stimulants like cocaine. A-68930 also increased grooming by lengthening the grooming bouts, and reduced locomotion and rearing responses. At the largest dose, immobility was increased. The anorectic effect of A-68930 may reflect, at least in part, the increased grooming it produces.
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