Spermotoxicity and tissue accumulation of chlordecone (Kepone) in male rats
作者:
RalphE. Linder,
ThomasM. Scotti,
W. Keith McElroy,
JohnW. Laskey,
LillianF. Strader,
Kevin Powell,
期刊:
Journal of Toxicology and Environmental Health
(Taylor Available online 1983)
卷期:
Volume 12,
issue 2-3
页码: 183-192
ISSN:0098-4108
年代: 1983
DOI:10.1080/15287398309530417
出版商: Taylor & Francis Group
数据来源: Taylor
摘要:
Adult male rats were fed diets containing 0, 5, 15, and 30 ppm chlordecone for 90 d and then either bred to untreated females or sacrificed for terminal studies. Chlordecone residues in liver, fat, and serum were determined in the treated males. Reproductive performance was unaffected, and no histologic changes in the male sex organs could be attributed to chlordecone treatment Reversible decreases in the motility and viability of epldidymal spermatozoa and decreased sperm reserves in the cauda epididymidis were observed in rats fed 15 or 30 ppm. No effect on sperm morphology or on sperm concentration in epididymal fluid was detected. Chlordecone accumulation in tissues was linearly related to dietary levels, with the highest chlordecone concentration occurring in the liver.
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