Hemodynamic alterations in canine acute lung injury induced with N‐nitroso‐N‐methylurethane
作者:
ROBERT SMITH,
BAHMAN VENUS,
MALI MATHRU,
YOICHI SHIRAKAWA,
期刊:
Critical Care Medicine
(OVID Available online 1984)
卷期:
Volume 12,
issue 7
页码: 576-578
ISSN:0090-3493
年代: 1984
出版商: OVID
数据来源: OVID
摘要:
Acute alveolar injury induced by subcutaneous injection of N-nitroso-N-methylurethane (NNNMU) closely resembles the pathology of human adult respiratory distress syndrome (ARDS). However, its effects on cardiovascular function have not been evaluated. We measured hemodynamic variables and venous admixture (Qsp/Qt at FIo20.21) and shunt fraction (Qsp/Qt at Fio21.0) in 7 dogs. The measurements were repeated when a single subcutaneous injection of 8.0 mg/kg NNNMU decreased PaO2on room air to 40 torr (phase I) and 30 torr (phase II). Within 5 to 7 days after injection, Pao2decreased to 40 torr, Qsp/Qt at Fio20.21 increased from 0.18 to 0.70, Qsp/Qt at Fio21.0 increased to 0.55, and pulmonary vascular resistance index (PVRI) increased from 213 ± 37 to 407 ± 42 dyne sec/cm5m2(p< .05). However, a decrease in mean arterial pressure (MAP) from 153 ± 16 to 131 ± 32 mm Hg was the only significant hemodynamic change. At phase II, decreased systemic vascular resistance index (SVRI) was the only significant hemodynamic alteration. We conclude that single subcutaneous injection of NNNMU produces hemodynamic and pulmonary dysfunction similar to that seen in human ARDS. This acute lung-injury model may be useful for evaluating different ARDS therapies.
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