Plasma levels of PRL, GH, FSH, LH, and TSH were studied at various intervals after electric stimulation of the amygdala, in 5 patients in whom electrodes had been chronically implanted in the course of their evaluation for surgical treatment of uncontrollable, temporal lobe seizures. Electric stimulation, but not sham stimulation, elicited in all cases a significant rise in plasma PRL. Plasma GH rose only in 1 patient and TSH in another. No significant changes in plasma FSH or LH were detected. It is suggested that a fine control mechanism of the hypothalamic hypophyseal final common pathway for the control of PRL secretion, may be mediated either by the ventral amygdalohypothalamic pathway or via the stria terminalis.