Absence of Cellular Hypersensitivity in Patients with Unexplained Hepatitis Following Halothane
作者:
Bryan Walton,
Anne Hamblin,
Dudley Dumonde,
Roy Simpson,
期刊:
Anesthesiology
(OVID Available online 1976)
卷期:
Volume 44,
issue 5
页码: 391-397
ISSN:0003-3022
年代: 1976
出版商: OVID
关键词: Anesthetics;volatile;halothane; Liver;hepatitis: Allergy. hypersensitivity;halothane
数据来源: OVID
摘要:
in vitrotests of cell-mediated immunity were performed using blood obtained from subjects with unexplained hepatitis following halothane anesthesia to determine whether sensitization to potentially antigenic products of halothane metabolism might exist. Both lymphocyte transformation and leukocyte migration-inhibition tests were undertaken in the presence of trifluoroacetylated human liver specific protein and trifluoroacetylated human serum albumin. All tests in the presence of these potential antigenic complexes were negative. The results support the view that cell-mediated hypersensitivity to trifluoroacetylated proteins does not contribute to the pathogenesis of hepatic dysfunction following halothane anesthesia
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