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Penbutolol Selective Membrane Sensor

 

作者: MarianaS. Ionescu,   RalucaI. Stefan,   G.E. Balutescu,   A.A. Bunaciu,   V.V. Cosofret,   HassanY. Aboul-Eneln,  

 

期刊: Analytical Letters  （Taylor Available online 1993）
卷期: Volume 26, issue 10  

页码: 2095-2105

 

ISSN:0003-2719

 

年代: 1993

 

DOI:10.1080/00032719308017454

 

出版商: Taylor & Francis Group

 

关键词: Penbutolol plastic membrane sensor;drug analysis;content uniformity;dissolution release

 

数据来源: Taylor

 

摘要:

The construction and performance characteristics of ion-selective PVC membrane electrode for penbutolol sulfate are described. The electrode, based on ion-pair complex with dinonylnaphthalenesulphonate anion, shows near-Nernstian response in the range 10−3to 5 × 10−6M drug concentration. Its selectivity relative to various cations is reported. Potentimetric methods are used to determine pure drug-substance and active principle in pharmaceutical preparation with good results. It was also applied to the determination of content uniformity and dissolution-rate of film-coated Betapresin® tablets.

 

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