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Time-Course of the Effect ofα-Methyl-p-Tyrosine on ACTH Secretion

 

作者: U. Scapagnini,   L. Annunziato,   G. Lombardi,   Ch. Oliver,   P. Preziosi,  

 

期刊: Neuroendocrinology  （Karger Available online 1975）
卷期: Volume 18, issue 3  

页码: 272-276

 

ISSN:0028-3835

 

年代: 1975

 

DOI:10.1159/000122406

 

出版商: S. Karger AG

 

关键词: α-Methyl-p-tyrosine (α-MpT);ACTH;Corticosterone (Plasma B);Nor-epinephrine (NE)

 

数据来源: Karger

 

摘要:

250 mg/kg i.p. of the methyl ester of α-methyl-p-tyrosine (α-MpT) produced a rapid increase (by 1 h) in immunoreactive plasma ACTH, whereas the hypothalamic norepinephrine (NE) concentration and plasma corticosterone (B) changed significantly only 6 h after the administration of the inhibitor. These data suggest that the norepinephrinergic inhibitory tonus of CRF-ACTH secretion depends on the availability of a rapidly utilized pool of transmitter, affected in a very short time by α-M

 

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