Failure to Detect a Second-Generation Effect in Female Mice after Neonatal Treatment with an Estrogen (Diethylstilbestrol)
作者:
J.-G. Forsberg,
A. Hailing,
期刊:
Cells Tissues Organs
(Karger Available online 1992)
卷期:
Volume 144,
issue 2
页码: 103-106
ISSN:1422-6405
年代: 1992
DOI:10.1159/000147292
出版商: S. Karger AG
关键词: Diethylstilbestrol;Genetic toxicity tests;Cell differentiation;Cervix uteri Female mice
数据来源: Karger
摘要:
Inbred female mice of the NMRI strain were treated subcutaneously with 5 µg diethylstilbestrol (DES) in olive oil or vehicle only for the first 5 days after birth. One group of DES-treated females was killed at the age of 8-12 weeks, and the uterine cervix and adjacent parts of the vagina and uterine horns prepared for histological studies. In all preparations, the cervical epithelial lining contained regions with heterotopic columnar epithelium (HCE) along 69-100% of the length of the common cervical canal. Ovaries from neonatally DES-treated females were grafted to 8-week-old ovariectomized control hosts and these hosts were mated to control males 2 weeks later. The hosts gave birth to normal-sized litters. The female offspring from these litters had a normal cervical epithelial lining and, in turn, gave birth to normal-sized litters. These results indicate that treatment of neonatal female mice with DES does not affect the female germ cells as far as concerns factors associated with the development of HCE or reduced fertility in the next generation
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