首页   按字顺浏览 期刊浏览 卷期浏览 Arterial Thrombosis Enhanced by an Acute Phase Response
Arterial Thrombosis Enhanced by an Acute Phase Response

 

作者: Ryan Jones,   Marjorie Braam,   Brian Cooley,  

 

期刊: Annals of Plastic Surgery  (OVID Available online 1996)
卷期: Volume 36, issue 1  

页码: 14-17

 

ISSN:0148-7043

 

年代: 1996

 

出版商: OVID

 

数据来源: OVID

 

摘要:

Induction of an acute phase response causes changes in the levels of specific plasma proteins. Fibrinogen is elevated to approximately twice its normal concentration by trauma, inflammation, or infection. In this study, an acute phase response was induced by subcutaneous turpentine injection in rats. Twenty-four hours later, an arterial model of thrombosis was created bilaterally in the femoral arteries. Patency at 1 and 7 days postoperatively was 24% (9/38) in comparison to 56% (20/36) in control (saline-injected) rats undergoing the same thrombosis model. Fibrinogen levels were elevated in the turpentine group to 5.3 ± 0.8 mg/ml at the time of the surgery and 7.2 ± 0.3 mg/ml 24 hours after surgery. In contrast, the control group had plasma fibrinogen levels of 2.5 ± 0.2 mg/ml at the time of surgery and 5.4 ± 0.5 mg/ml 24 hours postoperatively. These findings suggest that when an acute phase reaction has been induced several hours prior to a microvascular procedure, there may be an increased risk for development of arterial thrombosis.Jones R, Braam MJ, Cooley BC. Arterial thrombosis enhanced by an acute phase response. Ann Plast Surg 1996;36:14-17

 

点击下载:  PDF (352KB)



返 回