Biochemistry of muscle membranes in Duchenne muscular dystrophy
作者:
Lewis P. Rowland,
期刊:
Muscle&Nerve
(WILEY Available online 1980)
卷期:
Volume 3,
issue 1
页码: 3-20
ISSN:0148-639X
年代: 1980
DOI:10.1002/mus.880030103
出版商: Wiley Subscription Services, Inc., A Wiley Company
数据来源: WILEY
摘要:
AbstractIn Duchenne muscular dystrophy, as in other genetic diseases, there must be a biochemical abnormality. This fundamental genetic fault has not been identified, but several indirect lines of evidence suggest that the surface membranes of skeletal muscle are affected. The biochemical evidence implies abnormal egress of soluble enzymes and other proteins from muscle, abnormal permeability, and altered properties of membrane‐bound enzymes. As a result of the presumed genetic abnormality, functional properties are altered, and impaired regulation of intracellular calcium content could be responsible for the hallmarks of the disease—progressive weakness and degeneration of muscle. The evidence is by no means conclusive, however, and some of it is contradictory. Technical advances must be made before isolated membranes can be characterized biochemically. Other theories are also being evalua
点击下载:
PDF
(1880KB)
返 回