Teratogenicity of 3,3‐dimethyl‐1‐phenyltriazene in the rat: Gross malformations including micrognathism
作者:
Anthony A. Frank,
Daniel J. Thompson,
Evelyn A. Kazacos,
期刊:
Teratology
(WILEY Available online 1989)
卷期:
Volume 39,
issue 1
页码: 53-61
ISSN:0040-3709
年代: 1989
DOI:10.1002/tera.1420390107
出版商: Wiley Subscription Services, Inc., A Wiley Company
数据来源: WILEY
摘要:
Abstract3,3‐Dimethyl‐1‐phenyltriazene (DMPT), an alkylating agent, has been reported to be teratogenic in chickens, mice, and rats. One of the most commonly affected structures is the mandible; however, a complete description and incidence rates of all malformations produced have not been published. Rats were treated on day 12 of gestation (day 0 = sperm in vaginal smear) with a single intraperitoneal injection of 30 mg DMPT/kg. Fetuses were examined on each subsequent day of gestation for external and skeletal abnormalities. Standard soft tissue examinations were performed on day‐20 fetuses. A high percentage (≥80%) of treated litters contained numerous fetuses with micrognathism, cleft palates, syndactyly, adactyly, and misshapen digits and limbs. Lordosis, cerebellar and cerebral hypoplasia, decreased fetal size, and generalized delayed ossification were also observed. Dams exposed to DMPT had decreased food consumption and weight gains, although clinicopathologic and histopathologic evaluations failed to indicate other evidence of maternal toxicity. DMPT caused numerous permanent structural alterations that were not attributed to maternal
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