The determination of optimal sample sizes for estimating the difference between population means to a desired degree of confidence and precision is a question of economic significance. This question, however, is generally not discussed in statistics texts. Sample sizes to minimize linear sampling costs are proportional to the population standard deviations and inversely proportional to the square roots of the unit sampling costs. Sensitivity analysis shows that the impact of the use of equal rather than optimal sample sizes on the amount of sampling and its cost is not great as long as the unit costs and population variances are comparable.