Effect of Recombinant Human Erythropoietin Treatment on Hemodynamic Parameters in Continuous Ambulatory Peritoneal Dialysis and Hemodialysis Patients
作者:
Ana Fernández,
Nicanor Vega,
Francisco Jiménez,
Manuel Macía,
Eva Laraudiogoitia,
Luis Hortal,
Miguel Perdomo,
Celia Plaza,
Jose Carlos Rodríguez,
Leocadia Palop,
期刊:
American Journal of Nephrology
(Karger Available online 1992)
卷期:
Volume 12,
issue 4
页码: 207-211
ISSN:0250-8095
年代: 1992
DOI:10.1159/000168448
出版商: S. Karger AG
关键词: Recombinant human erythropoietin;Echocardiography;Hypertension;Continuous ambulatory peritoneal;dialysis Hemodialysis
数据来源: Karger
摘要:
We studied the hemodynamic changes and the incidence of hypertension after correction of anemia with recombinant human erythropoietin (rhEPO) in 25 hemodialysis (HD) and in 27 continuous ambulatory peritoneal dialysis (CAPD) patients with a mean age of 44.6 years and a mean time on dialysis of 43.6 months. We analyzed basal and final hemoglobin concentrations, time elapsed to reach target hemoglobin, rhEPO dosage, and the following echocardiographic parameters: left ventricular end-systolic and end-diastolic diameters and volumes, posterior wall thickness, interventricular septum, ejection fraction, fractional fiber shortening, cardiac output index, and peripheral vascular resistance index. We did not find any significant difference between HD and CAPD patients in basal and final hemoglobin, concentrations, time elapsed to reach target hemoglobin, dose of rhEPO received for response, and incidence of hypertension. Changes were more evident in HD patients, with a decrease of 15 % in cardiac output index and an equal increase of peripheral vascular resistance,. In the patients on CAPD, these variations were less important, with a decrease in cardiac output index of 10% and no significant change in peripheral vascular resistance. Despite both techniques showing the occurrence of hypertension, the left ventricular mass stabilized during the study time. We conclude that CAPD seems to modulate the changes observed in hemodynamic parameters after rhEPO treatment.
点击下载:
PDF
(984KB)
返 回