HYDROPHOBIZING EFFECT OF CATIONS ON ACIDIC PHOSPHOLIPID MEMBRANES
作者:
M. Mirza,
Y. Guo,
K. Arnold,
C.J.van Oss,
S. Ohki,
期刊:
Journal of Dispersion Science and Technology
(Taylor Available online 1998)
卷期:
Volume 19,
issue 6-7
页码: 951-962
ISSN:0193-2691
年代: 1998
DOI:10.1080/01932699808913225
出版商: Taylor & Francis Group
数据来源: Taylor
摘要:
By means of contact angle measurements with water and aqueous salt solutions, it is shown that plurivalent cations increase the hydrophobicity of negatively charged phospholipid vesicle membranes (consisting of phosphatidic acid, PA, or of phosphatidylserine, PS), but does not influence the hydrophobicity of neutral phospholipid membranes, (e.g., phosphatidylcholine, PC, at up to 200 mM of CaCl2). The hydrophobizing action of cations on PA and PS membranes is concomitant with the reduction in (negative) zeta potential with increasing cation concentrations. Trivalent cations, La3+, showed more effective in hydrophobizing negatively charged phospholipid membranes than divalent and monovalent cations. Except for hydrogen ions, monovalent cations do not show any appreciable hydrophobizing effect on lipid vesicle membranes at concentrations less than 1 M. The hydrophobizing effect on phospholipid membranes can also be used to explain the induction of lateral phase separation into patches of different phospholipids as well as cell fusion.
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