Transferrins and Heme-Compounds as Iron Sources for Pathogenic Bacteria
作者:
OttoB. R.,
VerweijA. M. J.J.,
MaclarenD. M.,
期刊:
Critical Reviews in Microbiology
(Taylor Available online 1992)
卷期:
Volume 18,
issue 3
页码: 217-233
ISSN:1040-841X
年代: 1992
DOI:10.3109/10408419209114559
出版商: Taylor&Francis
关键词: iron-uptake systems;heme uptake;virulence;iron-repressible outer membrane proteins
数据来源: Taylor
摘要:
AbstractThe low concentration of free iron in body fluids creates bacteriostatic conditions for many microorganisms and is therefore an important defense factor of the body against invading bacteria. Pathogenic bacteria have developed several mechanisms for acquiring iron from the host. Siderophore-mediated iron uptake involves the synthesis of low molecular weight iron chelators called siderophores which compete with the host iron-binding glycoproteins lactoferrin (LF) and transferrin (TF) for iron. Other ways to induce iron uptake, without the mediation of siderophores, are the possession of outer membrane protein receptors that actually recognize the complex of TF or LF with iron, resulting in the internalization of this metal, and the use of heme-compounds released into the circulation after lysis of erythrocytes. In this review, the nonsiderophore-mediated iron-uptake systems used by certain pathogenic bacteria are emphasized. The possible contribution of these iron-uptake systems to the virulence of pathogens is also discussed.
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