This study proposes an empirical approach that can lead to the sustainable management of groundwater resources. This approach enables a comprehensive understanding of an aquifer, delineates distinct hydrological scenarios, and recommends a set of operational activities for each sub-region of the aquifer. The paper focuses on the Coastal aquifer of the Gaza Strip region which has been divided into three sub-regions. The southern sub-region (WSW) is classified as scenario “+a2”, which indicates that it can be used as a multi-annual groundwater reservoir. The northern sub-region (NW-E) is designated scenario “-a2”, where the recommended operational measures include injection of freshwater in wells and cleaning of the surface environment. The third sub-region (CSE), is classified as scenario “-b2”, which requires severe management measures to correct both a negative hydrological and environmental situation. The approach also involves on-going monitoring of the aquifer, and can be considered as an empirical tool to provide preliminary guidelines for long-term groundwater management.