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Downregulation of CD28 Surface Antigen on CD4+and CD8+T Lymphocytes During HI...
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Downregulation of CD28 Surface Antigen on CD4+and CD8+T Lymphocytes During HIV‐1 Infection
作者:
Helen Choremi-Papadopoulou,
Vassilis Viglis,
Panos Gargalianos,
Theodore Kordossis,
Aliki Iniotaki-Theodoraki,
John Kosmidis,
期刊:
Journal of Acquired Immune Deficiency Syndromes
(OVID Available online 1994)
卷期:
Volume 7,
issue 3
页码: 245-253
ISSN:0894-9255
年代: 1994
出版商: OVID
关键词: HIV-1 infection;CD28 antigen;T-cell activation;CD4 and CD8 lymphocyte subsets;Activation markers.
数据来源: OVID
摘要:
SummaryA progressive significant decrease of CD28 surface antigen expression on CD4+(mean, 90, 86, 79,68% in stages I, II, III, and IV, respectively, versus 96% in normals), as well as on CD8+T lymphocytes (mean, 38, 32, 31, and 29% in stages I, II, III, and IV, respectively, versus 47% in normals) was observed during HIV-1 infection. The increase of cytotoxic/suppressor T cells, in both percentage and absolute numbers, that was observed in almost all HIV-1 patients, was associated with an increase of the CD8+cells lacking the CD28 surface antigen. The loss of CD28 antigen expression was parallel to the increase of CD38, human leukocyte antigen (HLA)-DR, and CD45RO antigen expression on T lymphocytes throughout the disease. Furthermore, a positive significant correlation within the CD4+but not the CD8+subset was observed between the percentage of cells lacking the CD28 antigen and the percentage of cells expressing the HLA-DR and CD38 antigens, a finding suggesting that the loss of CD28 antigen expression on CD4+lymphocytes may be associated with T-lymphocyte activation. Patients treated with zidovudine showed no significant differences in the percentages of either CD4+CD28+or CD8+CD28+T-cell subsets when compared to untreated patients. These phenotypic changes may be associated with the functional defects of T lymphocytes in HIV-1 infected individuals.
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