Pigeon and Dove Eggwhite Protect Mice Against Renal Infection Due to P FimbriatedEscherichia coli
作者:
JAMES JOHNSON,
TERRIEL BERGGREN,
期刊:
The American Journal of the Medical Sciences
(OVID Available online 1994)
卷期:
Volume 307,
issue 5
页码: 335-339
ISSN:0002-9629
年代: 1994
出版商: OVID
关键词: P fimbriae;Pyelonephritis;Urinary tract infection;Mouse model;Egg white;Adherenc;Inhibitors;Diseases of the kidney
数据来源: OVID
摘要:
Pigeon and dove eggwhite exhibit high level P1antigenic activity and are potent and specific inhibitors of adherence mediated by P fimbriae of uropathogenicEscherichia coli.To evaluate pigeon and dove eggwhite as P fimbrial receptor analogues in the prevention of ascending renal infection, mice were challenged with a P fimbriatedE. coliurosepsis isolate suspended in saline alone or in saline plus various inhibitors of adherence, including D-mannose, globoside, and chicken, dove, and pigeon eggwhite. D-mannose inhibited mannose-sensitive adherence but not P fimbrial adherence, and failed to prevent renal infection. Globoside and chicken eggwhite also failed to inhibit P fimbrial adherence; chicken eggwhite had little and globoside had no impact on renal infection. In contrast, dove and pigeon eggwhite eliminated P fimbrial adherence and significantly reduced the incidence and intensity of renal infection. These findings suggest that pigeon and dove eggwhite provide P1-antigen-specific protection against ascending renal infection in mice due to P fimbriated uropathogenicE. coli.
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