Immunohistochemical Study of c-erbB-2 Oncoprotein Expression in Extramammary Paget’s Disease
作者:
M. Nishi,
H. Yoshida,
M. Setoyama,
M. Tashiro,
期刊:
Dermatology
(Karger Available online 1994)
卷期:
Volume 188,
issue 2
页码: 100-102
ISSN:1018-8665
年代: 1994
DOI:10.1159/000247110
出版商: S. Karger AG
关键词: c-erbB-2;Extramammary Paget’s disease;Malignancy
数据来源: Karger
摘要:
Sections of formalin-fixed, paraffin-embedded tumor tissue from 20 patients with noninvasive extramammary Paget’s disease and 2 patients with invasive extramammary Paget’s disease were stained immunohistochemically by means of anti-c-erbB-2 product monoclonal antibody. Membrane staining of intraepidermal tumor cells was found in only 3 of 20 cases of noninvasive extramammary Paget’s disease. In the 2 invasive cases, tumor cells of invasive lesions and metastases were positive while intraepidermal tumor cells were neg
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