Effects of Hypercaloric Glucose Infusion on Lipid Metabolism in Injury and Sepsis
作者:
YVON CARPENTIER,
JEFFREY ASKANAZI,
DAVID ELWYN,
MALAYAPPA JEEVANANDAM,
FRANK GUMP,
ALLEN HYMAN,
ROBERT BURR,
JOHN KINNEY,
期刊:
The Journal of Trauma: Injury, Infection, and Critical Care
(OVID Available online 1979)
卷期:
Volume 19,
issue 9
页码: 649-654
ISSN:0022-5282
年代: 1979
出版商: OVID
数据来源: OVID
摘要:
Lipolysis was studied by measuring glycerol turnover (GTO) in injured and infected patients. GTO was elevated two to three times the normal values in five injured and four infected patients during D5W infusion. No correlation was found between GTO and plasma glycerol concentration in the two patient groups. GTO showed similar levels when measured during TPN in five injured and three infected patients. During TPN, plasma FFA levels remained unchanged in injured but decreased by 48% in septic patients. B-OH butyrate concentrations were high during D5W and dropped in both groups during TPN. Norepinephrine urinary output was high in both groups during D5W and TPN.Conclusions: 1) GTO was elevated two to three times the normal range in injury and infection; plasma glycerol concentration was not related to GTO. 2) In face of high catecholamine output, the insulin response to TPN did not inhibit TG breakdown but did decrease plasma ketone body concentrations.
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