Gene Expression in Low Oxygen Tension
作者:
TODD HELFMAN,
VINCENT FALANGA,
期刊:
The American Journal of the Medical Sciences
(OVID Available online 1993)
卷期:
Volume 306,
issue 1
页码: 37-41
ISSN:0002-9629
年代: 1993
出版商: OVID
关键词: Hypoxia;Anoxia;Transcription;Gene regulation;Erythropoietin;Transforming growth factor-β;Fos;Jun;Fibroblasts;Endothelial cells
数据来源: OVID
摘要:
Low oxygen tension is a feature of many physiologic and pathologic conditions, including wound healing, fibrosis, and neoplasia. Increasing evidence suggests that low oxygen tension induces the transcription of a number of genes, and that this process depends on the cellular context. The proteins synthesized from these genes enable cells to adapt to the hypoxic environment and/or to fulfill their functional roles. The regulatory regions responsible for the induction of erythropoietin gene transcription and synthesis in response to hypoxia/anemia appear to be cis-acting deoxyribonucleic acid sequences located within the 5' and 3' flanking regions of the erythropoietin gene. Other proteins induced by hypoxia include cytokines (platelet-derived growth factor-β chain, endothelin-1, transforming growth factor-β), enzymes (tyrosine hydroxylase, glycolytic enzymes), and stress proteins. The molecular mechanisms of the hypoxia, induced expression of these genes are poorly understood. A heme protein may act as the oxygen tension sensor, or the redox state of certain nuclear transcription factors may function as second messengers.
点击下载:
PDF
(545KB)
返 回