High‐fat diet promotes and causes distal shift of experimental rat colonic cancer—beer and alcohol do not
作者:
HowarthAndrewE.,
PihlEric,
期刊:
Nutrition and Cancer
(Taylor Available online 1985)
卷期:
Volume 6,
issue 4
页码: 229-235
ISSN:0163-5581
年代: 1985
DOI:10.1080/01635588509513829
出版商: Taylor&Francis Group
数据来源: Taylor
摘要:
AbstractIntestinal cancer was induced in inbred male D/A rats by 1,2‐dimethylhydrazine, and the interrelationships between a high‐fat (33.5% w/w) diet, beer and alcohol (4.8% v/v) ingestion, and tumor location and incidence were examined. The number of tumors per animal was significantly greater in both the small and large intestines of rats on the high‐fat diet, as opposed to the standard died. The 6‐fold increase in incidence of colorectal cancer occurred almost exclusively in the distal half of the large bowel; i.e., there was a highly significant (p<0.005) shift, similar to that seen in man in countries adopting high‐fat Western‐type diets. Neither alcohol nor beer ingestion affected the incidence of intestinal cancers, but beer was associated with a more distal distribution of small‐intestinal cancers in animals on the high‐fat diet. However, this was not considered sufficient evidence for any material effect of beer on experimental intestinal carcinogenesis.(Nutr Cancer 6, 229–235, 1985)
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