Nosological and Prognostic Distinctions in Schizophrenia: Pharmacological Validation in Terms of Therapeutic Antagonism between Anticholinergic Anti-Parkinsonism Drugs and Neuroleptics
作者:
Man Mohan Singh,
Stanley R. Kay,
期刊:
Neuropsychobiology
(Karger Available online 1978)
卷期:
Volume 4,
issue 5
页码: 288-304
ISSN:0302-282X
年代: 1978
DOI:10.1159/000117643
出版商: S. Karger AG
关键词: Anticholinergic-neuroleptic antagonism;Diagnostic types;Schizophrenia;Prognostic types;Therapeutic outcome;Schizophrenic process;Neuroleptic-responsiveness;Neuroleptic-resistant component
数据来源: Karger
摘要:
In studying the relationships between anticholinergic-neuroleptic interactions and the nosological and prognostic distinctions in schizophrenia, we have shown that these distinctions have clinicopathological meaning. The countertherapeutic anticholinergic effects seemed to be particularly evident in the good outcome, schizophreniform cases and differentiated between the three diagnostic subtypes. Such effects were most conspicuous in the catatonics who also had the most favorable prognosis, while the paranoids differed from others in not only showing the least anticholinergic effects but also in not conforming to the relationship between these effects and prognosis. The findings are briefly considered in relation to those with wheat gluten which has also been shown to be a countertherapeutic factor in schizophrenia in another study.
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