Interstitial Dendritic Cells
作者:
HartDerek N. J.,
McKenzieJudith L.,
期刊:
International Reviews of Immunology
(Taylor Available online 1990)
卷期:
Volume 6,
issue 2-3
页码: 127-138
ISSN:0883-0185
年代: 1990
DOI:10.3109/08830189009056624
出版商: Taylor&Francis
关键词: interstitial dendritic cell;passenger leucocyte
数据来源: Taylor
摘要:
Interstitial dendritic cells (IDC) were first identified in the interstitium of non-lymphoid organs as leucocytes which stained intensely with anti-MHC class II antibodies. These cells have been identified in several species including man, and can be distinguished from tissue macrophages by their immunological phenotype and cytochemical and functional characteristics. IDC appear to be closely related to lymphoid dendritic cells (DC), and have the capacity to bind antigen and stimulate T lymphocyte responses. It seems probable that they represent a stage of non-lymphoid dendritic cell differentiation necessary for antigen surveillance, similar to the Langerhans cell of the skin. Exposure to antigen appears to induce migration of these cells into adjacent lymphatics and subsequent localization in the interfollicular areas of lymph node, where the DC present processed antigen to activate a primary T cell response. The IDC has been identified as the passenger leucocyte within organ allografts which contributes substantially to graft immunogenicity, so that eradication of donor organ IDC improves organ graft survival.
点击下载:
PDF (1001KB)
返 回