A constitutive 65 kda chondrocyte protein as a target antigen in adjuvant arthritis in Lewis Rats
作者:
FeigeUlrich,
SchulmeisterAndreas,
MollenhauerJurgen,
BruneKay,
BangAnd Holger,
期刊:
Autoimmunity
(Taylor Available online 1994)
卷期:
Volume 17,
issue 3
页码: 233-239
ISSN:0891-6934
年代: 1994
DOI:10.3109/08916939409010659
出版商: Taylor&Francis
关键词: adjuvant arthritis;Autoantigen;Cytokeratin;heat-shock protein;autoimmune disease;immunotherapy
数据来源: Taylor
摘要:
The autoantigen in adjuvant arthritis in Lewis rats is still unknown despite the knowledge that the 65 kDa mycobacterial heat-shock protein (hsp) is involved in the disease process. T cells and antibodies obtained from rats with adjuvant arthritis respond to chondrocyte membrane antigen(s). In Western blots a 65 kDa chondrocyte membrane protein (CH65) is stained by sera from arthritic rats. In addition, spleen cells from rats with adjuvant arthritis proliferate in vitro to chondrocyte membranes and CH65 as antigens. Furthermore, pretreatment of rats with CH65 or mycobacterial hsp65 but not human hsp60, induces a significant retardation of the onset of adjuvant arthritis in Lewis rats. The data suggest that CH65 is a potential autoantigen involved in the pathogenesis of adjuvant arthritis in Lewis rats.
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