Release of Neurotransmitter Amino Acids from Rat Brain Synaptosomes and Its Regulation in Aging
作者:
G.V. Aprikyan,
K.G. Gekchyan,
期刊:
Gerontology
(Karger Available online 1988)
卷期:
Volume 34,
issue 1-2
页码: 35-40
ISSN:0304-324X
年代: 1988
DOI:10.1159/000212928
出版商: S. Karger AG
关键词: Glutamic acid;Aspartic acid;γ-Aminobutyric acid;Synaptosomes;rat
数据来源: Karger
摘要:
The release of neurotransmitter amino acids 14C-Asp, 14C-Glu and 14C-GABA from rat brain synaptosomes in aging is studied. It is established that K+-induced Ca2+-dependent and Ca2+-independent release of these amino acids decreases significantly in the old animals. K+ (40 mM) stimulates strongly their release for both ages, but the effect of K+ ions in old animals is less marked. Removal of Ca2+ has a greatly inhibitory effect on synaptosomal release in young as well as in old rats. The degree of inhibition does not depend on age, though it takes place at a lower level in old rats.
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