Growth cone inhibition – an important mechanism in neural development?
作者:
Jamie A. Davis,
Geoffrey M. W. Cook,
期刊:
BioEssays
(WILEY Available online 1991)
卷期:
Volume 13,
issue 1
页码: 11-15
ISSN:0265-9247
年代: 1991
DOI:10.1002/bies.950130103
出版商: Wiley Subscription Services, Inc., A Wiley Company
数据来源: WILEY
摘要:
AbstractSince the growth cone was first described a century ago by Cajal, considerable effort has been directed towards understanding the mechanisms responsible for its guidance. Traditionally, attention has focussed on the role of adhesive molecules in determining neural development. Recently, it has become apparent that inhibitory interactions may play a crucial part in axonal navigation. A common feature of inhibition seen in three model systems (peripheral nerve segmentation, retinotectal mapping and CNS/PNS segregation) is a collapse of the motile structures of the growth cone. It is increasingly clear that the identification of molecular mechanisms of inhibition, as well as those of adhesion, will be of fundamental importance to understanding neural development.
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