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Physical Factors Contributing to Hydrophobic Constant π

 

作者: Guang‐Zhong Yang,   Eric J. Lien,   Zong‐Ru Guo,  

 

期刊: Quantitative Structure‐Activity Relationships  （WILEY Available online 1986）
卷期: Volume 5, issue 1  

页码: 12-18

 

ISSN:0931-8771

 

年代: 1986

 

DOI:10.1002/qsar.19860050104

 

出版商: WILEY‐VCH Verlag

 

关键词: Hydrophobic constant;lipophilic character;dipole moment;molar volume;molecular weight;hydrogen bonding ability

 

数据来源: WILEY

 

摘要:

AbstractThe hydrophobicity constants (μ) of different aromatic substituents have been factored into three major components, a volume factor (MW, or Vw), an electronic factor as represented by dipole moment (μ), and H‐bonding factor. The following general equation has been shown to be applicable to a wide range of nonpolar to polar substituents, with only a few notable outliers: π = a · MW (or Vw) ‐ b · HB ‐ c · μ + d.The usefulness and the limitations of such a general correlation a

 

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