Hypothalamic morphology following ingestion of aspartame or MSG in the neonatal rodent and primate: A preliminary report
作者:
W. Ann Reynolds,
Veronica Butler,
Naomi Lemkey‐Johnston,
期刊:
Journal of Toxicology and Environmental Health
(Taylor Available online 1976)
卷期:
Volume 2,
issue 2
页码: 471-480
ISSN:0098-4108
年代: 1976
DOI:10.1080/15287397609529448
出版商: Taylor & Francis Group
数据来源: Taylor
摘要:
Neonatal mice received oral doses of monosodium glutamate (MSG) at levels of 0.25, 0.5, 1.0, 2.0, and 4.0 g/kg or aspartame at levels of 0.5, 1.0, 1.5, and 2.0 g/kg. Hypothalamic lesions were encountered at dose levels equal to or exceeding 0.5 g/kg (MSG) and 1.0 g/kg (aspartame). Aspartame administration resulted in a much smaller hypothalamic lesion than did equal dosages of MSG.
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