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Hypothalamic morphology following ingestion of aspartame or MSG in the neonatal rodent and primate: A preliminary report

 

作者: W. Ann Reynolds,   Veronica Butler,   Naomi Lemkey‐Johnston,  

 

期刊: Journal of Toxicology and Environmental Health  (Taylor Available online 1976)
卷期: Volume 2, issue 2  

页码: 471-480

 

ISSN:0098-4108

 

年代: 1976

 

DOI:10.1080/15287397609529448

 

出版商: Taylor & Francis Group

 

数据来源: Taylor

 

摘要:

Neonatal mice received oral doses of monosodium glutamate (MSG) at levels of 0.25, 0.5, 1.0, 2.0, and 4.0 g/kg or aspartame at levels of 0.5, 1.0, 1.5, and 2.0 g/kg. Hypothalamic lesions were encountered at dose levels equal to or exceeding 0.5 g/kg (MSG) and 1.0 g/kg (aspartame). Aspartame administration resulted in a much smaller hypothalamic lesion than did equal dosages of MSG.

 

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