Dose-response Relationship for Chromosome Aberations induced in Human Lymphocytes by 18 MeV Electron Beam Irradiation
作者:
E. A. H. Lashin,
H. F. Moustafa,
E. M. Elaasar,
Y. Y. Bakir,
S. D. Al Zenki,
期刊:
Isotopenpraxis Isotopes in Environmental and Health Studies
(Taylor Available online 1990)
卷期:
Volume 26,
issue 1
页码: 40-43
ISSN:0021-1915
年代: 1990
DOI:10.1080/10256019008624219
出版商: Taylor & Francis Group
关键词: biological effects;biological indicators;chromosomal aberrations;chromosomes;dose-response relationships;electron beams;genetic effects;lymphocytes;mutation frequency;radiotherapy
数据来源: Taylor
摘要:
Dose response curves for lymphocyte chromosome aberration frequencies using X- and gamma radiations became an important and reliable indicators as biological dosimeters especially in radiation accidents and professional over exposures. Nowadays electron beams therapy are frequently used for their advantages in cases of tumours under or near to the body surface. Dose-response curves for these electron beams are rarely published. Human peripheral blood lymphocytes were in vitro irradiated with various low and high doses (0.1 Gy to 4.9 Gy) of 18 MeV electron beam to utilize such a dose-response curve using chromosome aberration frequencies as a biological marker. Then we compared this biological curve with physically obtained curves normally used in planning for radiotherapy treatment. It is interesting to find a significant difference between both of them. The biological curve is generally higher in value and that the aberrations induced by 93% of a dose is significantly higher and deeper in site than those aberrations induced by the 100% dose calculated physically. If the above observation is confirmed by detailed studies, it would be of importance to the radiotherapist to plan for isodose curves according to biological determinations.
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